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临床试验/NCT06978348
NCT06978348招募中不适用

Establish an Artificial Intelligence Clinical Decision Support System for Patients With Carotid/Vertebral Artery Stenosis.

Shanghai Jiao Tong University School of Medicine1 个研究点 分布在 1 个国家目标入组 244,296 人开始时间: 2025年5月10日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
244,296
试验地点
1
主要终点
Establish an artificial intelligence clinical decision support system for patients with carotid/vertebral artery cerebrovascular stenosis,Early identification of patients who may have cerebral infarction.

研究概览

简要总结

Establish an artificial intelligence clinical decision support system for patients with carotid/vertebral artery cerebrovascular stenosis, early identification of patients who may have cerebral infarction. With the support of this project, it is expected that a secondary prevention clinical decision support system for chronic stroke will be established, which is likely to become an important auxiliary tool for the management of cerebrovascular diseases in the future.

详细描述

Stroke is a disease with a high mortality rate and incidence rate, and it is one of the main reasons for high medical expenses. Ischemic stroke accounts for approximately 85% of all subtypes of stroke. Carotid artery and vertebral artery stenosis are definite and intervenable risk factors for ischemic stroke. However, the selection of clinical intervention timing and methods for patients with cerebrovascular stenosis is limited to the rate of carotid/vertebral artery stenosis and the symptoms of the patients. Cerebral infarction caused by carotid/vertebral artery stenosis often leads to irreparable neurological deficits. Currently, there is a lack of comprehensive evaluation methods for the severity of ischemic cerebrovascular diseases such as carotid/vertebral artery stenosis, and even less a clinical decision-making system that can predict the progression of the disease. This project intends to take the demographic data and clinical information of patients with cerebrovascular stenosis from multiple centers and ethnic groups as the entry point, combine the multidisciplinary advantages of imaging, ultrasound, clinical medicine and computer science, and use artificial intelligence technology to construct a model for predicting the disease progression and the probability of adverse cardiovascular events such as stroke in patients with cerebrovascular stenosis. Based on this, the investigators' hospital intends to develop a set of secondary prevention management tools and clinical decision support systems for ischemic cerebrovascular diseases.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Patients undergoing vascular (carotid/vertebral artery) B-ultrasound

排除标准

  • Patients with missing clinical data such as medical history, cerebrovascular ultrasound results and biochemical data

结局指标

主要结局

Establish an artificial intelligence clinical decision support system for patients with carotid/vertebral artery cerebrovascular stenosis,Early identification of patients who may have cerebral infarction.

时间窗: December 2025

1.The clinical history, imaging data, blood test indicators and other data of patients who completed carotid/vertebral artery cerebrovascular ultrasound examinations from January 2012 to December 2022 were collected to establish a data set;2. This dataset was statistically analyzed in combination with the general risk factors of cerebrovascular diseases and the specific risk factors of carotid artery stenosis;3. The above-mentioned model was trained using the existing clinical database of patients with carotid and cerebrovascular stenosis in the hospital;4. Through machine learning, an artificial intelligence clinical decision support system for patients with carotid/vertebral artery stenosis is established to identify patients with early cerebrovascular stenosis who require surgical intervention, and even asymptomatic patients.

次要结局

  • Analyze the risk factors leading to stroke(December 2025)

研究者

发起方
Shanghai Jiao Tong University School of Medicine
申办方类型
Other
责任方
Principal Investigator
主要研究者

Yijun Cheng

Principal investigator

Shanghai Jiao Tong University School of Medicine

研究点 (1)

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