Investigating attentional function and cognitive fluctuations in Lewy body disease
- Conditions
- Topic: Dementias and Neurodegenerative Diseases Research NetworkSubtopic: DementiaDisease: DementiaMental and Behavioural DisordersDementia
- Registration Number
- ISRCTN97853380
- Lead Sponsor
- orthumbria Tyne and Wear NHS Foundation Trust (UK)
- Brief Summary
2016 results in: https://www.ncbi.nlm.nih.gov/pubmed/26705763
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 96
1. For dementia patients: that they meet defined clinical criteria for diagnosis of dementia (dementia with Lewy bodies, Parkinson's disease with dementia, or Alzheimer's dementia) and Mini-Mental State Examination (MMSE) test score of more than 12
2. For healthy controls: No history of psychiatric or neurological brain disease and MMSE score more than 26 and has capacity to consent to participate
3. All aged 60 years and above, either sex
1. Contraindications for or unwillingness to undergo MR imaging
2. Severe dementia (MMSE score less than 12), as such subjects will have difficulty fully understanding the nature and extent of the proposed research
3. Presence of other severe or unstable medical illnesses
4. Subjects with a history of visual impairment secondary to glaucoma, cataract, or macular degeneration as this could affect the ability of subjects to perform the visual attention task with LBD
5. Medications: subjects on benzodiazepines, antipsychotics or anticonvulsants will not be included as these can effect the EEG activity patterns
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional MR BOLD activations to attentional network task, measured at end of study
- Secondary Outcome Measures
Name Time Method 1. Diffusion tensor measures of white matter, measured at end of study<br>2. Spatio-temporal EEG activations to attentional network task, measured at end of study