Investigating attentional function and cognitive fluctuations in Lewy body disease: a functional magnetic imaging and electrophysiology multicentre non-randomised observational diagnosis cross-sectional study

orthumbria Tyne and Wear NHS Foundation Trust (UK)0 个研究点目标入组 96 人开始时间: 2010年10月21日最近更新: 2018年6月11日

适应症

试验速览

•1. For dementia patients: that they meet defined clinical criteria for diagnosis of dementia (dementia with Lewy bodies, Parkinson's disease with dementia, or Alzheimer's dementia) and Mini-Mental State Examination (MMSE) test score of more than 12
•2. For healthy controls: No history of psychiatric or neurological brain disease and MMSE score more than 26 and has capacity to consent to participate
•3. All aged 60 years and above, either sex

•1. Contraindications for or unwillingness to undergo MR imaging
•2. Severe dementia (MMSE score less than 12), as such subjects will have difficulty fully understanding the nature and extent of the proposed research
•3. Presence of other severe or unstable medical illnesses
•4. Subjects with a history of visual impairment secondary to glaucoma, cataract, or macular degeneration as this could affect the ability of subjects to perform the visual attention task with LBD
•5. Medications: subjects on benzodiazepines, antipsychotics or anticonvulsants will not be included as these can effect the EEG activity patterns

发起方

orthumbria Tyne and Wear NHS Foundation Trust (UK)