Investigating attentional function and cognitive fluctuations in Lewy body disease: a functional magnetic imaging and electrophysiology multicentre non-randomised observational diagnosis cross-sectional study

orthumbria Tyne and Wear NHS Foundation Trust (UK)0 sites96 target enrollmentOctober 21, 2010

Overview

Phase: 未知
Intervention: Not specified
Conditions: Topic: Dementias and Neurodegenerative Diseases Research Network
Sponsor: orthumbria Tyne and Wear NHS Foundation Trust (UK)
Enrollment: 96
Status: Completed
Last Updated: 7 years ago

Registry

who.int

Start Date

October 21, 2010

End Date

April 30, 2013

Last Updated

7 years ago

Study Type

Interventional

Sex

All

Sponsor

orthumbria Tyne and Wear NHS Foundation Trust (UK)

•1\. For dementia patients: that they meet defined clinical criteria for diagnosis of dementia (dementia with Lewy bodies, Parkinson's disease with dementia, or Alzheimer's dementia) and Mini\-Mental State Examination (MMSE) test score of more than 12
•2\. For healthy controls: No history of psychiatric or neurological brain disease and MMSE score more than 26 and has capacity to consent to participate
•3\. All aged 60 years and above, either sex

•1\. Contraindications for or unwillingness to undergo MR imaging
•2\. Severe dementia (MMSE score less than 12\), as such subjects will have difficulty fully understanding the nature and extent of the proposed research
•3\. Presence of other severe or unstable medical illnesses
•4\. Subjects with a history of visual impairment secondary to glaucoma, cataract, or macular degeneration as this could affect the ability of subjects to perform the visual attention task with LBD
•5\. Medications: subjects on benzodiazepines, antipsychotics or anticonvulsants will not be included as these can effect the EEG activity patterns