Changes in Brain Synchronization During Perceptual and Linguistic Tasks in Schizophrenic Patients

• Conditions: Schizophrenic Patients
• Interventions: Device: Magnetoencephalograph (MEG)

• Registration Number: NCT01550211
• Lead Sponsor: Shalvata Mental Health Center

Brief Summary

This study aims to identify electrophysiological correlates of impaired perceptual and linguistic processes in chronic schizophrenic patients, un-medicated first-episode schizophrenic patients and their healthy relatives.

Following administrating some questionnaires (demographic details and psychiatric history questionnaire, handedness questionnaire, reading abilities test and positive and negative symptoms questionnaire) and performing a perception test and a verbal abstract intelligence test, participants will conduct a brain scan during a series of perceptual and linguistic tasks.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-03
• Study Start: 2012-03
• Study First Submitted: 2012-03-07
• Study First Submitted QC: 2012-03-07
• Last Update Submitted: 2012-03-07
• Study First Posted: 2012-03-09
• Last Update Posted: 2012-03-09
• Primary Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Inclusion criteria for chronic patients:

• Hebrew native speakers.
• Diagnosis of schizophrenia with a history of more than one episode.
• Capable and willing to provide informed consent.

Inclusion criteria for naive patients:

• Hebrew native speakers.
• Diagnosis of schizophrenia with a history of only one episode and unmedicated.
• Capable and willing to provide informed consent.

Inclusion criteria for patients' relatives (control group 1):

• Hebrew native speakers.
• Without any psychiatric history.
• Have a child and/or a sibling with schizophrenia.

Inclusion Criteria for students (control group 2):

• Hebrew native speakers.
• Without any psychiatric history.

Exclusion Criteria

Exclusion Criteria for patient groups (chronic and "naïve"):

• Left handedness.
• Reading disability.
• Visual perception disability.
• Brain damage and/or a history of seizures.
• Impaired intelligence.
• Metal implants.

Exclusion Criteria for control groups (family members and students):

• Psychiatric history.
• Left handedness.
• Reading disability.
• Visual perception disability.
• Brain damage and/or a history of seizures.
• Impaired intelligence.
• Metal implants.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Students	Magnetoencephalograph (MEG)	Healthy students from Bar-Ilan University
Schizophrenic patients' relatives	Magnetoencephalograph (MEG)	Healthy family members (parents or siblings) of the schizophrenic participants (chronic and naive)
Naive schizophrenic patients	Magnetoencephalograph (MEG)	Naive patients with a diagnosis of schizophrenia, a history of only one psychotic episode and un-medicated
Chronic schizophrenia patients	Magnetoencephalograph (MEG)	Chronic patients with a diagnosis of schizophrenia and a history of more than one psychotic episode

Primary Outcome Measures

Name	Time	Method
Magnetic field amplitude and source	45 minutes

Trial Locations

Locations (1)

Shalvata MHC; 🇮🇱 Hod-Hasharon, Israel