Relationship between coagulation disturbances and microcirculation alterations and the development of multi-organ failure in sepsis
Completed
- Conditions
- blood poisoningsepsis1000401810011954
- Registration Number
- NL-OMON39381
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 36
Inclusion Criteria
- patients 18 years and older admitted to the intensive care unit with
severe sepsis and septic shock
Exclusion Criteria
-active bleeding at time of inclusion
-pre-existing haematological disorders such as protein C or S deficiency, haemophila
-therapeutic anticoagulation
-recently documented (within 3 months of study entry) or highly suspected deep vein
thrombosis or pulmonary embolus
- pregnancy
- chronic liver failure with an protrombin prolongation (international normalized ratio >1.2)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Thromboelastometry parameters measured with ROTEM®:<br /><br>• Clotting time (CT)<br /><br>• Clot formation time (CFT)<br /><br>• alfa-angle<br /><br>• Maximum clot firmness (MCF)<br /><br>• Maximum lysis (ML) and Lysis index (LI)<br /><br><br /><br>Sidestream dark field imaging parameters:<br /><br>MFI (microvascular flow index), the heterogeneity index, PVD (perfused vessel<br /><br>density density), PPV (proportion of perfused vessels).</p><br>
- Secondary Outcome Measures
Name Time Method