Association of inflammation and coagulation markers with levels of C-reactive proteine in healthy volunteers

• Conditions: atherosclerosis; occlusive heart disease; 10082206; 10003216

• Registration Number: NL-OMON30501
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Male sex, or postmenopausal female, age 50 years or older

Exclusion Criteria

Other disease
Medication use
(Other) cardiovascular risk factors

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- hsCRP<br /><br>- coagulation<br /><br>- thrombin generation: F1+2<br /><br>- fibrinolytic system: D-dimers, PAI-1, tPA<br /><br>- endothelial cell activation: vWF<br /><br>- inflammation<br /><br>- monocytic expression of CD11b, CD18, TF, CD62L<br /><br>- cytokines: IL-6, IL-8, TNFalpha (receptor)<br /><br>- chemokines: MCP-1, E-selectin<br /><br>- sunendothelium: MMP-9, MPO</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>