Objective, Prospective Measurement of Anterior Chamber Cell Grading Using Anterior Chamber Ocular Coherence Tomography
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Number of Participants With Identified Inflammatory Cells on OCT Scan
研究概览
简要总结
Optical Coherence Tomography (OCT) is routinely used in ophthalmic clinical practice. It uses infrared light to image patient's eyes. Some patients, such as those with an inflammatory disease called uveitis or those who have just undergone cataract surgery, have intraocular inflammation. This intraocular inflammation commonly manifests as cells that can be seen on routine microscopic clinical examination. However, the only currently available method to quantify this intraocular inflammation is by manually counting on the microscopic clinical examination. The investigators plan to use the OCT machine to image patient's eyes. The investigators will then use the images obtained from the OCT to objectively quantify the degree of intraocular inflammation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age over 18 years old
- •Intervention Arm:
- •Active anterior chamber inflammation in at least one eye as diagnosed by clinical exam
- •One of the following: 1) diagnosis of uveitis OR 2) undergone cataract extraction surgery within the previous 30 days
- •Control Arm:
- •No active intraocular inflammation based on clinical exam
排除标准
- •Corneal opacities in the affected eye
- •Anyone judged unable to understand or consent to study participation
研究组 & 干预措施
Uveitis and Cataract Imaging Group
Subjects will undergo up to three optical coherence tomography scans.
干预措施: Optical Coherence Tomography (OCT) (Device)
Control
Control subjects will undergo a brief, non-contact eye exam and then undergo up to three optical coherence tomography scans.
干预措施: Optical Coherence Tomography (OCT) (Device)
Control
Control subjects will undergo a brief, non-contact eye exam and then undergo up to three optical coherence tomography scans.
干预措施: Eye Exam (Other)
结局指标
主要结局
Number of Participants With Identified Inflammatory Cells on OCT Scan
时间窗: Through study completion, up to 1 year.
This measure pertains to the identification of cells in OCT scan of the participants. The inflammatory cells to be identified refer to white blood cells. The anterior segment OCT scan was used to attempt to identify these cells in the anterior chamber of the eyes of the participants.
次要结局
- Change in Cell Density Identified by OCT Scans Over Time(Baseline and up to 8 weeks.)
研究者
David S. Chu, MD
Clinical Associate Professor
Rutgers, The State University of New Jersey