The Incretin Effect in Patients With Chronic Pancreatitis
- Conditions
- Chronic PancreatitisType 2 Diabetes Mellitus
- Registration Number
- NCT00638573
- Lead Sponsor
- University Hospital, Gentofte, Copenhagen
- Brief Summary
The phenomenon that oral glucose elicits a higher insulin response than does intravenous (iv) glucose, even at identical plasma glucose (PG) profiles (isoglycemia), is called the incretin effect. In type 2 diabetes mellitus (T2DM) the incretin effect has been shown to be markedly reduced or even abolished. It is not known whether the reduced incretin effect in T2DM is a primary event leading to T2DM or if it is merely a consequence of the diabetic state. To answer this question the investigators plan to estimate the incretin effect in 8 patients with secondary diabetes mellitus (DM) to chronic pancreatitis (CP) and compare it to the incretin effect of 8 patients with CP and normal glucose tolerance (NGT). Eight patients with T2DM and 8 healthy control subjects are studied for comparison. The incretin effect is measured by a 50-g oral glucose tolerance test and an isoglycemic intravenous glucose infusion.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 32
- Diagnosis of chronic pancreatitis with secondary diabetes mellitus
- Diagnosis of chronic pancreatitis with normal glucose tolerance
- Diagnosis of type 2 diabetes
- Normal level of hemoglobin
- Normal level of se-creatinine
- GAD-65 autoantibodies
- ICA autoantibodies
- Albuminuria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Gentofte University Hospital
🇩🇰Hellerup, Copenhagen County, Denmark