Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance

Completed

• Conditions: Renal Artery Blood Flow; Renal Venous Return; Acute Kidney Injury; Renal Microcirculation

• Registration Number: NCT06090773
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical and medullary microcirculatory blood flow and renal function; and to find the value of ultrasonographic assessment of renal blood flow indices for evaluating prognosis in patients with sepsis.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-01
• Study First Submitted: 2023-10-14
• Study First Submitted QC: 2023-10-14
• Study First Posted: 2023-10-19
• Primary Completion: 2023-12-01
• Study Completion: 2023-12-30
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-07
• Last Update Posted: 2024-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• Age between 18-85 years old; Control group: patients with non-acute kidney injury after ICU general surgery; Observation group: patients who met the diagnostic criteria of AKI: Scr elevation ≥26.5 umol/L within 48h; Scr elevation exceeding 1.5 times and more than the basal value within 7d; and decrease in urine output (<0.5 ml/kg/h) with a duration of 6h or more.

Exclusion Criteria

• Those who did not meet the inclusion criteria or refused to be enrolled; patients with underlying end-stage renal disease or requiring long-term dialysis; renal transplant patients; patients with other underlying systemic diseases causing renal dysfunction (SCr > 88.4 umol/L); those who were unable to obtain a clear renal ultrasound view; those with suspected contrast allergy; those with pulmonary arterial systolic blood pressure ≥ 90 mm Hg; and those who were pregnant or breastfeeding women.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
30-day major renal adverse events	30-day	Follow-up of patients with prognostic indicators of renal function within 30 days of enrolment, such as blood creatinine and the need for renal replacement therapy.
Renal venous return	Day 1,Day 3,Day 5, Day 7	Ultrasonographic assessment of renal venous reflux profiles.
renal microcirculation	Day 1,Day 3,Day 5, Day 7	Evaluation of renal microcirculation by ultrasonography.
Renal artery blood flow	Day 1,Day 3,Day 5, Day 7	Ultrasound assessment of renal artery resistance index, and renal artery blood flow.

Trial Locations

Locations (1)

Rongping Chen; 🇨🇳 Beijing, Beijing, China