Non-invasive Diagnostics of Pulmonary Hypertension With Dual Energy Computed Tomography - Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Pulmonary blood flow and volume determined by dual energy computed tomography
研究概览
简要总结
The aim of the study is to determine relevant hemodynamic parameters for the diagnostics of pulmonary arterial hypertension (PAH) by dynamic contrast enhanced dual-energy CT (DE-CT). In this pilot study the investigators investigate patients who underwent right heart catheterisation with DE-CT to determine hemodynamic parameters and control the results by other clinical investigations. The investigators expect that using this non-invasive method, parameters relevant for the diagnosis of the patients with PAH, like pulmonary blood volume, blood flow and perfusion heterogeneity, can be determined.
详细描述
Pulmonary arterial hypertension (PAH) is a rare, life-threatening disease. It is characterized by the elevation of pulmonary arterial pressure and pulmonary vascular resistance. A remodeling of small pulmonary vessels characterized by the proliferation of the adventitia, the hypertrophy of the media and fibrosis of the intima can be observed on the microscopic level.
Non-invasive techniques for hemodynamic assessment and identification of early pulmonary vascular remodeling and pulmonary hypertension have a marked practical advantage as compared to invasive right heart catheterization, however, their accuracy and reliability is not well established.
In the present study the investigators examine patients who underwent right heart catheterization and are scheduled for a thorax CT with an additional dynamic contrast-enhanced DE-CT protocol and derive established parameters for the diagnosis of PAH as well as novel parameters from the CT scans. These are compared to results from the right-heart catheterization and other investigations routinely carried out on these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with right heart catheterization data
排除标准
- •patients with decreased renal function
- •patients who received CT in the previous six months
- •intolerance of contrast material
- •other standard CT contraindications
研究组 & 干预措施
pulmonary vascular disease
Dual-energy computed tomography investigation
干预措施: Dual-energy computed tomography investigation (Radiation)
结局指标
主要结局
Pulmonary blood flow and volume determined by dual energy computed tomography
时间窗: measurements with right heart catheterisation within 1 month
determination of differences in pulmonary blood flow and volume of pulmonary hypertension patients
次要结局
- Comparison of dual energy computed tomography derived data with clinical findings of pulmonary hypertension patients(measurements with right heart catheterisation within 1 month)
- Lung perfusion heterogeneity determined by dual energy computed tomography(measurements with right heart catheterisation within 1 month)