Colonoscopy in liver transplants (LT): prevalence and risk of advanced adenomas post-LT

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 350

Inclusion Criteria

Group A: Post liver transplant patients without pre-LT colonoscopy
Patients who
- Have a follow-up of at least 5 years after receiving their first LT.
- Have had orthotopic liver transplantation (OLT).
- Have had non-PSC transplant indications;Group B
• B1 Post liver transplant patients with pre-LT colonoscopy negative findings:
Patients who
- Have a follow-up of at least 5 years after receiving their first LTx
- Have had orthotopic liver transplantation (OLT)
- Are Non-PSC transplant indications
Colonoscopy results within 5 years of post-LT follow-up in post-LTx patients will also be included in the analyses
Patients with a post-LTx colonoscopy before 5 years of post-LTx follow-up who are still alive at time at inception, will also be asked to participate in the post liver transplant colonoscopy program (>= 5 year FU)

B2 Post liver transplant patients with pre-LTx colonoscopy positive findings:
Patients who
- Have a follow-up of at least 5 years post-LT
- Have had orthotopic liver transplantation (OLT)
- Have had non-PSC transplant indications
If patients have 3 or more adenomas at pre-LT colonoscopy (which require intensified surveillance work-up in the Dutch polypectomy guideline10), the follow-up colonoscopy results within 3 years of follow-up after the index colonoscopy in post-LTx patients will be included in the analyses. If patients did not receive their appropriate 3-year surveillance colonoscopy, they will be asked for inclusion.

Exclusion Criteria

Patients who:
- have had an other bowel screening procedure pre-LT such as barium enema and/or sigmoidoscopy)
- are unable or not willing to give informed consent
- do have coagulopathy (prothrombin time < 50% of control; partial thromboplastin time > 50 seconds) or patients who have anticoagulants (marcoumar or sintrom) that can not be stopped
- are under 18 years of age
- have had auxiliary LTx
- have PSC
- are known with IBD ( UC or Crohn*s disease)
- have undergone a total colectomy
- do not have a post-LTx follow-up colonoscopy and are dead at time of inception

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint is defined as the prevalence and risk of advanced colorectal<br /><br>neoplasia detected by a post-LT colonoscopy program compared to the<br /><br>asymptomatic general population.</p><br>

Secondary Outcome Measures