The Effect of High-Flux Hemodialysis on HemoglobinConcentrations in Patients with CKD: Results of theMINOXIS Study
Not Applicable
- Conditions
- D64.9Anaemia, unspecified
- Registration Number
- DRKS00007612
- Lead Sponsor
- niversity of Würzburg Department of Internal medicine Division of Nephrology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 221
Inclusion Criteria
Patients with CKD who were treated by hemodialysis had to be at least 18 years of age and to have been receiving treatment for anemia with the ESA darbepoetin-alfa for at least 6 months.
Exclusion Criteria
Exclusion criteria were serious comorbid conditions with a life expectancy of < 2 years,
single-needle hemodialysis,
use of a permanent catheter,
planned kidney transplantation,
and pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint of the<br>study was the effect of high-flux versus low-flux hemodialysis<br>on hemoglobin concentration. Therefore, the intraindividual<br>change in hemoglobin concentration between<br>beginning (month 0) and end (month 12) of the study period<br>was calculated and compared between the two treatment<br>groups.
- Secondary Outcome Measures
Name Time Method Secondary endpoints were the effects of<br>high-flux versus low-flux hemodialysis on inflammatory<br>status, oxidative stress, and nutritional status. As was<br>done for calculations of the primary endpoint, the intraindividual<br>changes in albumin, hsCRP, oxidative LDL, and<br>myeloperoxidase concentrations between months 0 and<br>12 were determined and compared between the two treatment<br>groups.