the effect of lacto ovo vegetarian and normal diets in nonalcoholic fatty liver disease
- Conditions
- onalcoholic Fatty Liver Disease..Nonalcoholic steatohepatitis (NASH)K75.81
- Registration Number
- IRCT20140208016529N2
- Lead Sponsor
- Vice Chancellor for Research, Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Over-weight or obese patients with the nonalcoholic fatty liver disease confirmed with imaging techniques
increased levels of liver enzymes (serum levels of alanine aminotransferase and aspartate aminotransferase more than 40 U/L);
Body Mass Index (BMI) of them is greater than 24.9 and lower than 40
Alcohol consumption
Pregnant and lactating women
Any known forms of hepatic or metabolic disease except NAFLD, such as hereditary hemochromatosis, Wilson’s disease, cirosis,
other metabolic disease
history of gastric bypass or intestine surgery
Taking hepatotoxic drugs such as calcium channel blocker, methotrexate, amiodarone, chloroquine and anti inflammatory drugs;
Using nutrition supplements or vegetarian diets
Hormone Therapy
Patients with a history of hypothyroidism,
Cushing’s syndrome
renal failure
kidney stones.
Participants with less than 80% of adherence to the dietary plan are going to be excluded.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method iver enzymes (ALT, AST, ALP). Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Using Microgram/ml - laboratory kit.;Lipid profile (TG, LDL, HDL, Total cholestrol). Timepoint: The first day of the study and the last day of 12th week. Method of measurement: laboratory kit.;Liver steatosis index. Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Sonography.
- Secondary Outcome Measures
Name Time Method Waist to hip ratio. Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Non-stretchable tape without any pressure.;Body Mass Index (BMI). Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Weight (kilograms) divided by the square of height (meters).;Sistolic and diastolic blood pressure. Timepoint: The first day of the study and the last day of 12th week. Method of measurement: By mercury sphygmomanometer.