NCT01847807已完成3 期
The Cardiac and Kidney Protection of Astragalus in Subjects With Metabolic Syndrome
LanZhou University1 个研究点 分布在 1 个国家目标入组 210 人开始时间: 2011年1月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- index of cardiac function
研究概览
简要总结
Metabolic syndrome have the damages on tissues and organs in heart、kindey and vessels. In this study, prospective randomized, controlled, parallel designed ,different doses of Astragalus Mongolia, Gansu Longxi produce treat on the MS patients, and then use real-time quantitative PCR and Western Blotting to detect the index of oxidative stress 、angiotensin-converting enzyme 2 mRNA expression and proteins.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 years or older, meet the diagnostic criteria of MS
- •non-allergic with the astragalus
- •agree to conduct clinical trials and those who signed the informed consent
排除标准
- •patients with resistant hypertension
- •renal disease requiring dialysis
- •heart failure NYHA ⅢorⅣ;
- •complications of diabetes
- •thyroid disease
- •unstable coronary heart disease
- •peripheral vascular disease
- •acute cerebral vascular disease11.pregnancy、 planned pregnancy
- •patients with anti-oxidants
- •acute infection
- •other organic dysfunction, such as the liver, respiratory system, blood system, and other rheumatic diseases.
研究组 & 干预措施
High-dose Astragalus group
Active Comparator
treatment with 10 gram astragalus
干预措施: high dose astagalus (Drug)
Low-dose Astragalus group
Active Comparator
treatment with 5 gram astragalus
干预措施: low dose Astragalus (Drug)
结局指标
主要结局
index of cardiac function
时间窗: one year
ues echocardiography to measure the cardiac function
次要结局
- blood pressure(one year)
研究者
Jing Yu
cheif of cardiology
LanZhou University
研究点 (1)
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