A Comparative Study Between the Use of Dexmedetomidine Versus Dexamethasone as Adjuvant to Bupivacaine in Ultrasound-guided Transversus Abdominis Plane Block for Post-operative Pain Relief in Patients Undergoing Lower Open Abdominal Surgeries
试验速览
- 阶段
- 4 期
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- 1st time for rescue analgesia
研究概览
简要总结
Randomized controlled clinical Trial to compare the efficacy and duration of postoperative analgesia achieved after adding dexmedetomidine or dexamethasone to bupivacaine in TAP block for lower open abdominal surgeries.
详细描述
A Comparative study between the use of dexmedetomidine versus dexamethasone as adjuvant to bupivacaine in ultrasound-guided transversus abdominis plane block for post-operative pain relief in patients undergoing lower open abdominal surgeries
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients, Age 20-60 years. Elective operation under general anesthesia. Physical Status: ASA I and II Patients. Body mass index 25-35 kg/m2.
排除标准
- •Infection at site of injection.
- •Patient refusal.
- •Psychiatric or physical illness that lead to inability to cooperate, speak or read.
- •Abdominal operations under spinal anesthesia.
- •History or evidence of coagulopathy.
- •Known allergies to drugs used .
- •Preexisting neurological disorders.
研究组 & 干预措施
Group A (n=15): (Dexamethasone group)
Patients will receive 20 ml 0.25% bupivacaine plus 4 mg dexamethasone on each side TAB bock.
干预措施: Dexmedetomidine (Drug)
Group B (n=15): (Dexmedetomidine group)
Patients will receive 20 ml 0.25% bupivacaine plus 0.5 mcg/kg of dexmedetomidine on each side TAB block.
干预措施: Dexmedetomidine (Drug)
Group C (n=15): (control group)
Patients will receive 20 ml 0.25% bupivacaine on each side TAB block.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
1st time for rescue analgesia
时间窗: first 24 hours post-operatively
Time to first analgesia requirment(starting from drug injection)
次要结局
- Pain score- Visual Analogue Score (VAS)(First 24 hours post-operatively.)
研究者
Yasser Sayed Sobhy
Anesthesia specialist
Ain Shams University