The role of inactive follicle stimulating hormone in ovarian dysfunction in galactosemia.

Completed

• Conditions: infertility in galactosemia (inherited metabolic disorder); 10021605; 10033283; 10014701

• Registration Number: NL-OMON31697
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

galactosemia
ovarian dysfunction

Exclusion Criteria

normal ovarian function
endocrinological or gynecological tumors

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Estradiol response (yes/no) after recombinant FSH and LH. Estradiol response<br /><br>is defined as (*E2) > 30 pg/ml (Fanchin et al. 1994)<br /><br><br /><br>2) FSH glycan structure characterization in galactosemia women</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Baseline FSH (follicle stimulating hormone), LH (luteinizing hormone) AMH<br /><br>(anti- Müllerian hormone) and inhibin are measured at baseline. AMH and inhibin<br /><br>have not been well documented in the galactosemia population. These<br /><br>measurements can be relevant to the understanding of ovarian dysfunction.</p><br>