A randomized, double-blind, split-faced study comparing A.I. Clearing Treatment with 0.1% adapalene versus 0.1% adapalene in treatment of mild to moderate degree acne vulgaris

Phase 2

• Conditions: mild to moderate degree acne vulgaris; acne vulgaris; acne; adapalene; glycolic acid; salicylic acid; gluconolactone; licochalcone A; moisture; A.I. Clearing Treatment

• Registration Number: TCTR20171031005
• Lead Sponsor: Beiersdorf (Thailand) Co., Ltd.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-31
• Study Completion: 2018-01-10
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Male or female, 18-40 years old
2. Mild to moderate acne vulgaris by Acne Consensus Conference (ACC) criteria

Exclusion Criteria

1. previous phototherapy/laser within 4 weeks or use topical/systemic for treat acne within 2
2. who has other skin lesion or skin disease in study area
3. pregnancy or lactation
4. allergy to adapalene, glycolic acid, salicylic acid, gluconolactone, licochalcone A
5. immunocompromised host
6. psychiatric problem

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
inflammatory lesions of acne 0, 1, 2, 4 weeks counting

Secondary Outcome Measures

Name	Time	Method
erythema (side effect) 0, 1, 2, 4 weeks Likert scale (0, 1, 2, 3, 4),scale (side effect) 0, 1, 2, 4 weeks Likert scale (0, 1, 2, 3, 4),burning (side effect) 0, 1, 2, 4 weeks Likert scale (0, 1, 2, 3, 4),itching (side effect) 0, 1, 2, 4 weeks Likert scale (0, 1, 2, 3, 4),transpeidermal water loss 0, 1, 2, 4 weeks Tewameter®,skin hydration 0, 1, 2, 4 weeks Corneometer®,acne grading 0, 1, 2, 4 weeks Acne Consensus Conference (ACC),radiance visual analog scale 0, 1, 2, 4 weeks visual analog scale (VAS) for degree of sleepiness,Investigator’s Global Assessment Acne (IGA) 0, 1, 2, 4 weeks Likert scale (0, 1, 2, 3, 4, 5),Patient’s Global Assessment Acne (PGA) 0, 1, 2, 4 weeks Likert scale (0, 1, 2, 3, 4, 5)