Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technque

Not Applicable

Completed

• Conditions: Root Resorption
• Interventions: Biological: injectable PRF

• Registration Number: NCT04410679
• Lead Sponsor: Fayoum University

Brief Summary

Currently Endodontics looks forward for regeneration rather than repair. Regenerative endodontic therapy was limited to pulp revascularization of necrotic pulp in immature teeth , followed by mature teeth. Recently pulp revascularization technique by induction of blood clot was applied in the treatment of inflammatory root resorption. So far, no clinical study for management of teeth with inflammatory internal root resorption by using injectable PRF revascularization has been described in the literature. Thus, this is the first clinical attempt to manage inflammatory root resorption in necrotic incisor teeth using injectable PRF regenerative approach.

Detailed Description

13 teeth in a total of 10 patients with inflammatory root resorption will be treated using revascualrization technique, iPRF will be prepared and unjected in the canal after previous canal disinfection with calcium hydroxide for 2-4 weeks. cBCT will be taken preoperative and 12 month follow up period, also clinical and radiographic follow uo will be considered every 3 months for 1 year.

Study Timeline

• Study Start: 2018-06-03
• Primary Completion: 2019-06-06
• Study Completion: 2020-05-02
• Study First Submitted: 2020-05-27
• Study First Submitted QC: 2020-05-27
• Study First Posted: 2020-06-01
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-01
• Last Update Posted: 2021-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• patients 13-30 years old
• no sex predilection
• medically free
• Suffering from internal inflammatory root resorption in permanent anterior mature teeth
• associated with or without periapical radiolucency
• no or grade I tooth mobility, and a pocket depth <3 mm

Exclusion Criteria

• old age
• Medically medically compromised patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
injectabl PRF for treatment of internal root resorption	injectable PRF	-

Primary Outcome Measures

Name	Time	Method
change in volumetric size of internal root resorption lesions	12 months	Measuring volumetric dimensions of resorption lesion pre and postoperatively using CBCT

Secondary Outcome Measures

Name	Time	Method
change in volumetric size of periapical lesions	12 months	Measuring volumetric dimensions of periapical lesion pre and postoperatively using CBCT

Trial Locations

Locations (1)

Faculty of dentistry Fayoum University; 🇪🇬 Fayoum, Egypt