Geriatric Patients, Hemodynamics, Delirium, and Cerebral Inflammation in Orthopedic Surgery
Not Applicable
Recruiting
- Conditions
- F05R54Delirium, not induced by alcohol and other psychoactive substancesSenility
- Registration Number
- DRKS00030710
- Lead Sponsor
- niversitätsklinikum Rostock
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 156
Inclusion Criteria
elective total hip arthroplasty (THA) or total knee arthroplasty (TKA)
- general anesthesia with or without peripheral nerve block
Exclusion Criteria
- known psychiatric disorders (psychosis, major depression) or other cognitive impairment
- language barrier or impaired hearing
- no legal competence
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of postoperative delirium or neurocognitive disorders<br>- Testing neurocognitive disorders (MoCA-Test preoperative, day of surgery, 1.-5. and 90. postoperative day)<br>
- Secondary Outcome Measures
Name Time Method Evaluation of risk factors of a postoperative delirium<br>- postoperative pain by NRS-Scale (2h postoperative, 6h postoperative, 22pm on operation day, 1.-5. postoperative day in the morning and in the evening)<br>- anticholinergic medication <br>- Preoperative evaluation of heart failure (nt-proBNP preoperative)<br>- intraoperative risk factors (blood loss, clotting factors, medication, cerebral oximetry)<br>- biomarkers as an indication of neuroinflammation, blood-brain barrier damage or neuronal damage (e.g. protein S100B, NT-proCNP or systemic inflammation parameters).<br>- biomarkers of kidney injury (proEnkephalin, TIMP-2, IGFBP-7)<br><br>Evaluation of time of reconvalescence after total hip arthroplasty or total knee arthroplasty<br>- LUCAS-Index preoperative<br>- Barthel-Index (ADL-Score) preoperative, 1.-5. postoperative day<br>- record of organ dysfunction 1.-5. postoperative day