Patients undergoing laparoscopic surgery for gall bladder stone or other gall bladder diseases will be divided into three groups and given ropivacaine or ropivacaine+dexmedetomidine or normal saline through nebulization in the peritoneum to compare their effect in controlling pain after surgery.
Phase 4
- Conditions
- Health Condition 1: K801- Calculus of gallbladder with othercholecystitisHealth Condition 2: K801- Calculus of gallbladder with othercholecystitis
- Registration Number
- CTRI/2024/05/066721
- Lead Sponsor
- Rajendra Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a) The patient giving written and informed consent for study.
b) Patients posted for elective laparoscopic cholecystectomy.
c) Patients with ASA grade I and II.
d) Male and female patients aged between 18-70 years.
Exclusion Criteria
a. Patients having a clinical diagnosis of acute pancreatitis.
b. Patients having acute preoperative pain other than biliary colic.
c. Patients undergoing chronic pain treatment or on anti-epileptic.
therapy.
d. Patients with severe renal or hepatic impairment.
e. Patients with history of alcohol or drug addiction.
f. Patients having allergy to the study drugs.
g. Patients with cognitive impairment or communication problems.
h. Pregnant or lactating patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To record the time of requirement of first rescue analgesic.Timepoint: Visual Analogue Scale Score <br/ ><br>3hours post-surgery <br/ ><br>6hours post-surgery <br/ ><br>12hours post-surgery <br/ ><br>24hours post-surgery
- Secondary Outcome Measures
Name Time Method a) To record the hemodynamic parameters- systolic blood pressure, diastolic blood pressure, heart rate and MAP every after intraperitoneal nebulization till the end of surgery. <br/ ><br> <br/ ><br>b) To record incidence of nausea and vomiting after the operative procedure to the requirement of first rescue analgesic.Timepoint: Baseline <br/ ><br>5minutes after nebulization <br/ ><br>10minutes after nebulization <br/ ><br>15minutes after nebulization <br/ ><br>30minutes after nebulization <br/ ><br>45minutes after nebulization <br/ ><br>60minutes after nebulization <br/ ><br>75minutes after nebulization <br/ ><br>90minutes after nebulization <br/ ><br>105minutes after nebulization