The prevention of progression in CKD of medication adherence to AST-120 in patients with non-dialysis chronic kidney disease (CKD) and significance of measurement indoxyl sulfate as an indicator of medication adherence
Not Applicable
- Conditions
- non-dialysis chronic kidney disease
- Registration Number
- JPRN-UMIN000023724
- Lead Sponsor
- Jichi Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with a gastrointestinal disorder 2) AFR,RPGN(acute phase), Advanced nephrotic syndrome (albumin<2g/dl), Transplanted kidney 3) Severe heart failure (NYHA3 or more),Serious arrhythmia, Myocardial infarction or PCI within 6 months. 4) T1DM,and T2DM 5) AST, ALT less than 5 times as much as upper limit of standard value. 6) progressive cancer 7) Pregnant or women of childbearing potential unwilling to use effective means of contraception. 8) Patients who cannot signed an informed consent 9) Allergy to AST-120 10) Any other medical conditions disable to comply with the protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Medication adherence Serum creatinine eGFR indoxyl sulfate(Serum, 24 hour urine)
- Secondary Outcome Measures
Name Time Method BUN Urinany microalbumin Urinany protein NAG B2-Mg