Fluid Resuscitation With HES 200/0.5 10% in Severe Burn Injury

Phase 3

Completed

• Conditions: Survival; Renal Failure
• Interventions: Drug: Fluid resuscitation

• Registration Number: NCT01120730
• Lead Sponsor: University of Zurich

Brief Summary

HES 200/0.5 10% is equal to ringers lactat solution.

Detailed Description

30 Patients were enrolled to the study, either to the hyperoncotic HES 200/0.5 (10%) group or to the crystalloids only group. After a treatment protocol of 72 hours we collected data about complications like pulmonary failure and abdominal compartment syndrome. Furthermore, we addressed the question of incidence of mortality and renal failure.

Study Timeline

• Study Start: 1997-04
• Primary Completion: 1998-09
• Study Completion: 2009-03
• Study First Submitted: 2010-04-28
• Status Verified: 2010-05
• Study First Submitted QC: 2010-05-07
• Last Update Submitted: 2010-05-07
• Study First Posted: 2010-05-11
• Last Update Posted: 2010-05-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• All burn victims with burned surface area bigger than 20%

Exclusion Criteria

• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
HES	Fluid resuscitation	Fluid resuscitation with HES
ringers lactat	Fluid resuscitation	Standard treatment

Primary Outcome Measures

Name	Time	Method
Intensive care unit mortality	28 days	28 days

Secondary Outcome Measures

Name	Time	Method
fluid amount during the first 72 hours	28 days	Fluid resuscitation after burn

Trial Locations

Locations (1)

University Hospital Zurich; 🇨🇭 Zurich, Switzerland