A study of appropriate fluid volume for resuscitation (evaluation of stroke volume variation under spontaneous respiration)

Not Applicable

• Conditions: Patients with a decrease in effective intravascular volume; dehydration, hemorrhagic shock, septic shock, and so on)

• Registration Number: JPRN-UMIN000006484
• Lead Sponsor: ational center for global health and medicine

Brief Summary

Patients (n= 37) with septic shock who were fitted with FloTrac sensor. The mean of lactate value, IVC diameters, SVV values during initial fluid resuscitation vs. "stable svv" were 6.0 vs.1.8 mmol/L, 11 vs. 19 mm and 18.6 vs.8.8%, respectively (p < 0.001). Fluctations in SVV curves calculated by fast Fourier transformation resulted in a Lorentzian spectrum. The amplitude of all curves peaked at frequency = 0 and became significantly lower when "SVV stable" than during fluid therapy (1.3 vs.3.7%; p < 0.001).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-10-05
• Study Completion: 2013-12-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

1) Patients rejected intensive care management 2) Patients with terminal stage of malignant disease 3) Patients without informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
o increasing of SVI under fluid resuscitation shows that the effective intravascular volume is achieved by fluid resuscitation. At this point, the following parameters are measured, vital signs, diameter of IVC, blood gas data, arterial lactate, ejection fraction, central venous pressure, ScvO2, and SVV value. We detect the best parameter for appropriate fluid resuscitation volume using receiving operating curve analysis.