Opioid and ventilatory control during sleep

Phase 1

Withdrawn

• Conditions: Healthy volunteers; Blood - Other blood disorders

• Registration Number: ACTRN12606000392561
• Lead Sponsor: Woolcock Institute of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-09-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

BMI<30 kg/m2.

Exclusion Criteria

1. History of drug abuse. 2. History of symptomatic or known sleep apnea, heavy snoring, shift work sleep disorder or other sleep disorder. 3. Chronic insomnia and/or chronic pain for more than 6 months. 4. History of severe physiological or psychological illness. 5. Subjects with current physical complaints (such as flu or rhinitis) will not be included until symptoms are clear for a week.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arousal and ventilatory responses to hypoxia and hypercapnia during sleep[The responses would be tested during the second active night and its matching control night. During the 2 nights, the responses would be tested once for hypoxia and once for hypercapnia during stage 2 sleep (stable sleep).]

Secondary Outcome Measures

Name	Time	Method
Sleep-disordered breathing and Upper airway resistance[Upper airway resistance would be tested just before bed time on the first active night and its matching control night. ];Sleep-disordered breathing would be tested continuously throughout that two nights.[Monitored continuously throughout the 2 study nights]