Reversal of the respiratory effect of morphine and morphine-6-glucuronide by naloxone: a clinical study using healthy volunteers

Not Applicable

Completed

• Conditions: Respiratory depression by opioids; Respiratory; Respiratory depression

• Registration Number: ISRCTN59442355
• Lead Sponsor: eiden University Medical Centre (LUMC) (The Netherlands)

Brief Summary

2010 results in https://doi.org/10.1097/ALN.0b013e3181d5e29d (added 26/03/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-07-04
• Study Completion: 2007-01-01
• Last Update Posted: 12 April 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Healthy volunteers over 18 years of age

Exclusion Criteria

1. Obesity (Body Mass Index [BMI] more than 30)
2. Presence of medical disease (heart, lung, liver, kidney, neurological disease, diabetes, pyrosis, diaphragmatic hernia)
3. Presence of psychiatric disease
4. History of chronic alcohol or drug use
5. Allergy to study medications
6. Possibility of pregnancy
7. Lactating females

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Minute ventilation and pain response to heat pain

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures