Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers

Recruiting

• Conditions: ketamine; opioid-induced respiratory depression

• Registration Number: NL-OMON24921
• Lead Sponsor: MC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Healthy male or female volunteers;

- Age: 18 - 40 years;

Exclusion Criteria

- Known or suspected neuromuscular or a (family) history of any neuromuscular disease;

- A history of allergic reaction to food or medication including study medication;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- effect of ketamine on ventilation after OIRD.

Secondary Outcome Measures

Name	Time	Method
- effect of ketamine on ventilation<br /><br>- arterial blood sampling for PK<br /><br>- hemodynamic effect