Reversal of opioid-induced respiratory depression (OIRD) by ketamine in healthy volunteers * the ORKA trial
Completed
- Conditions
- opioid-geinduceerde ademdepressieOpioid-induced respiratory depression
- Registration Number
- NL-OMON43104
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Healthy male and female volunteers, aged 18 and older
Exclusion Criteria
- Known or suspected neuromuscular or a (family) history of any neuromuscular disease;
- A history of allergic reaction to food or medication including study medication;
- Any current or previous medical (including high blood pressure), neurological or psychiatric illness (including a history of anxiety);
- Alcohol abuse (> 21 units/week);
- Illicit drug use in the past 30 days before inclusion;
- Pregnancy or lactation;
- Participation in any medical or drug trial in the month prior to the current study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Ventilation</p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>