Investigating the timing of high dose rate (HDR) brachytherapy with external beam radiation therapy (EBRT) in intermediate and high risk localised prostate cancer patients and its effects on toxicity and quality of life

Completed

• Conditions: Prostate cancer; Cancer

• Registration Number: ISRCTN15835424
• Lead Sponsor: Southend University Hospital NHS Foundation Trust

Brief Summary

2015 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/25926023

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-10
• Study Completion: 2017-01-01
• Last Update Posted: 14 January 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

1. Patient age >18 years
2. Histologically diagnosed Prostate cancer, stages T1b-T3bN0M0
3. Any Gleason score
4. Any PSA level
5. Patient able to consent and fill in the questionnaires

Exclusion Criteria

1. Previous TURP/HoLEP Laser Prostatectomy
2. Any Metastatic Disease
3. IPSS>20
4. Pubic arch interference
5. Lithotomy position
6. If Anaesthesia is not possible
7. Rectal fistula
8. Prior pelvic radiotherapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prospective assessment of genitourinary toxicities according to the treatment sequence of HDR Brachytherapy and EBRT.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Treatment outcomes including biochemical response and survival<br> 2. Prospective assessment of gastrointestinal toxicities according to the treatment sequence of HDR brachytherapy and EBRT<br> 3. Assessment of Radiotherapy Planning Challenges including Image Guided Radiotherapy<br>