Can improved housing provide additional protection against clinical malaria over current best practice?

Not Applicable

Completed

• Conditions: Malaria; Infections and Infestations

• Registration Number: ISRCTN02622179
• Lead Sponsor: Durham University (UK)

Brief Summary

2016 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/27255167 2021 results in https://pubmed.ncbi.nlm.nih.gov/33838737/ (added 13/04/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-09-23
• Study Completion: 2017-02-01
• Last Update Posted: 26 April 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 805

Inclusion Criteria

Houses must meet the following criteria to be selected:
1. Thatched roofs
2. Intact walls (no cracks)
3. Be single-storey square buildings
4. Open eaves
5. No more than four rooms
6. No ceiling (which is equivalent to closed eaves)
7. No screening
8. At least two resident children aged six months to 13 years old (needed in case the study child leaves the study)

Children must be:
1. Aged 6 months to 13 years old
2. Resident in houses enrolled in the study
3. Whose parents/carers give written, informed consent for their child to be included in the study

Assent will also be sought from eligible children >11 years old after the purpose of the study and what is required has been explained to them according to their capability. In the case of school-age children, only those who live in their village during term-time will be eligible for enrolment. In order for the results from this study to be as generalizable as possible, no distinctions will be made in terms of medical condition or physical health.

Exclusion Criteria

1. Children for whom informed consent is not or cannot be provided
2. Children aged under 6 months or over 13 years on 1st June for the year of survey
3. Children expected to be non-residence during several month of the transmission season

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess whether improved housing reduces the burden of clinical malaria where coverage of LLINs is high. Incidence of clinical malaria determined by active case detection (ACD) and defined as body (axillary) temperature of =37.5oC, together with the presence of Plasmodium falciparum parasites detected by microscopy. Incidence will be measured from June to December in 2015 and 2016.