Priming Effects of Aerobic Exercise on Cognitive Training of Patients With Ischemic and Hemorrhagic Stroke

Fondazione Don Carlo Gnocchi Onlus1 site in 1 country30 target enrollmentNovember 12, 2022

ConditionsIschemic Stroke Hemorrhagic Stroke

Overview

Phase: N/A
Intervention: Not specified
Conditions: Ischemic Stroke
Sponsor: Fondazione Don Carlo Gnocchi Onlus
Enrollment: 30
Locations: 1
Primary Endpoint: Neuropsychological test scores
Status: Recruiting
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this clinical trial is to test the effects of aerobic exercise and BDNF on patients with ischemic and hemorrhagic stroke during a computerized cognitive training.

The main questions it aims to answer are:

Does a moderate intensity aerobic exercise, prior to a cognitive training, allow a better performance?
Is it possible to exploit the timing of rehabilitation interventions to obtain greater effects? Participants will be divided in 2 groups. The experimental group will first perform 20 minutes of pedaling as a moderate intensity aerobic exercise. It will then participate in one-hour cognitive training sessions, with the aim of training attentional, working memory and executive functions. The control group will carry out the same interventions but in reverse order.

The researchers will compare the results of the cognitive training in the two groups to verify if the order of the interventions influences the results themselves.

Registry

clinicaltrials.gov

Start Date

November 12, 2022

End Date

May 2023

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Fondazione Don Carlo Gnocchi Onlus

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients with a clinical diagnosis of stroke, both ischemic and haemorrhagic.
•Patients admitted to the Specialist Rehabilitation Unit 1 of the "E. Spalenza - Don Gnocchi "of Rovato.
•Overall score in the MoCA test ³ 26
•In case of a diagnosis of aphasia, a test of verbal comprehension ("Token Test") with score in the norm, P.E. \> 1
•Hypertonic and spasticity picture compatible with the performance of motor activity of pedaling expected in the EA session.
•Tolerance of physical exercise
•Incoming electrocardiogram normal and free of anomalies

Exclusion Criteria

•Overall score in the MoCA test \<26
•In case of a diagnosis of aphasia, a test of verbal comprehension ("Token Test") with pathological or borderline score, P.E. £
•Documented diagnosis of neurodegenerative diseases with impact on performance cognitive.
•Severe acquired brain injury
•Illiteracy
•Status of hypertonus and spasticity not compatible with the performance of motor training
•Excessive fatigue: the patient does not tolerate moderate intensity physical activity and accuses excessive fatigue during the preliminary test
•Electrocardiogram at entrance with anomalies and / or altered
•Ischemic heart disease
•Cardiac disorders that are contraindications for aerobic activity of moderate intensity

Outcomes

Primary Outcomes

Neuropsychological test scores

Time Frame: Change in the neuropsychological test scores at 1 month

The experimental hypothesis is to obtain better scores in the experimental group on the neuropsychological tests used. T-tests and delta scores will be used to determine the quantitative change in the score.