The Transition From Blastomere to Trophectoderm Biopsy: Comparing Two PGS Strategies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 383
- 主要终点
- Ongoing clinical pregnancy rate
研究概览
简要总结
Shortly after the implementation of Comprehensive Chromosome Screening (CCS) techniques for Preimplantation Genetic Screening (PGS) came the transition in biopsy timing. Trophectoderm biopsy is meant to overcome the limitations of cleavage stage biopsy and single cell analysis.
详细描述
The investigators have recently introduced this new approach and a frozen-thawed policy of euploid blastocysts is routinely performed.
This is a single centre retrospective study in patients undergoing a PGS cycle. The aim of the study is to assess the results obtained in a PGS programme after the implementation of a new biopsy timing and transfer policy. Results obtained in PGS cycles with blastocyst biopsy and frozen-thawed embryo transfer were analysed in comparison to cycles with cleavage stage biopsy and fresh blastocyst transfer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Own gametes
- •PGS for: advanced maternal age, repeated implantation failure, recurrent miscarriages, severe male factor, and previous affected pregnancies
排除标准
- •PGS cycles with gamete donation
- •Altered karyotypes
- •Combined Preimplantation genetic diagnosis (PGD)+PGS cycles
结局指标
主要结局
Ongoing clinical pregnancy rate
时间窗: 20 weeks after embryo transfer
Clinical pregnancy confirmed by ultrasound
次要结局
- Number of available euploid blastocysts per cycle(Up to 15 days after embryo biopsy)
- Miscarriage Rate(Until 20 weeks after embryo transfer)
- Implantation Rate(6 weeks after embryo transfer)
研究者
Lluc Coll Lujan
Principal investigator
Institut Universitari Dexeus