Synchronizing Blastocyst in Frozen Embryo Transfer

Not Applicable

Completed

• Conditions: Embryo Implantation
• Interventions: Other: synchronizing blastocysts

• Registration Number: NCT03128970
• Lead Sponsor: Al-Yasmeen Fertility and Gynecology Center

Brief Summary

The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-21
• Study First Submitted: 2017-04-21
• Study First Submitted QC: 2017-04-21
• Study First Posted: 2017-04-25
• Primary Completion: 2018-01-15
• Study Completion: 2018-05-10
• Status Verified: 2019-06
• Last Update Submitted: 2019-06-25
• Last Update Posted: 2019-06-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 742

Inclusion Criteria

1. Patients who will agree to participate and assign an informed consent form
2. Only blastocyst transfer FET cycles
3. Patients undergoing FET after their 1st IVF or ICSI cycle with no pregnancy at the fresh transfer
4. Freeze-all cycles due to OHSS
5. Freeze-all cycles due to poor endometrium
6. Age 19-33 at the time of randomization.
7. Their frozen blastocysts are 3 or less grade of expansion.
8. Female with a ≥12 AFCs
9. Endometrial thickness ≥ 8mm at the time of ovulation
10. Women with their male partners will give only fresh semen
11. Women who have no uterine abnormality by ultrasound
12. BMI ≤ 31

Exclusion Criteria

1. Cycles undergoing preimplantation genetic diagnosis.
2. Women who have previous two cycles of implantation failure at fresh transfer
3. Women who have previous two FET failed cycles
4. Any uterine pathology (myomas, adenomyosis, endocrinopathies, thrombophilia, chronic pathologies, acquired or congenital uterine abnormalities)
5. Patients with severe endometriosis
6. Presence of uni- or bilateral hydrosalpinx
7. Recurrent pregnancy loss.
8. Any medical condition that affect fertility.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
synchronized frozen/thawed hatching blastocysts	synchronizing blastocysts	blastocyst thawing (with three or less grade of expansion) will take place the day before embryo transfer in order to reach hatching stage

Primary Outcome Measures

Name	Time	Method
Ongoing implantation rate	12 weeks	ultrasound detection of ongoing gestational sacs with heartbeats after 12 weeks of gestation per transferred embryos

Trial Locations

Locations (2)

Ganna Fertility and Gynecology Center; 🇪🇬 Cairo, Egypt

Al-Yasmeen fertility and gynecology center; 🇪🇬 Banhā, Egypt