aser assisted hatching is beneficial for cases that use vitrified oocytes from egg donor cryo banks

Completed

• Conditions: Oocyte donation and vitrification; Pregnancy and Childbirth

• Registration Number: ISRCTN21836222
• Lead Sponsor: IAKENTRO Advanced Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-31
• Last Update Posted: 20 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 182

Inclusion Criteria

Oocyte donor inclusion criteria:
1. Up to 32 years old
2. Body mass index of less than 30 kg/m2
3. Regular menstrual cycles of 25–35 days
4. Two normal ovaries based on transvaginal scan findings
5. No polycystic ovary syndrome
6. No known endometriosis
7. No gynecological or medical disorders
8. Agreed to donate their oocytes for treatment anonymously and altruistically
9. Known fertility and good ovarian response
10. Blood sample given for karyotype and screening for previous viral infection (hepatitis B and C, human immunodeficiency virus, syphilis), thalassemia and cystic fibrosis
11. A single stimulation cycle was included for each donor

Recipient inclusion criteria:
1. Up to 50 years old
2. No history of endometriosis
3. First oocyte donation cycle
4. Blood screening for karyotype and previous viral infections (hepatitis B and C, human immunodeficiency virus, syphilis,) thalassemia and cystic fibrosis, for both the recipient and their partners
5. Screened for hysterosalpingogram
6. Diagnostic hysteroscopy to eliminate cases presenting hydrosalpinx or intrauterine pathology
7. Receive a mock transfer in a cycle previous to their donation cycle and if difficulty was encountered a cervical dilatation was performed
8. The recipient’s partner has no severe male infertility indication

Exclusion Criteria

Vitrified egg donation exclusion criteria:
1. When warmed oocytes are less than 9
2. When survived oocytes after warming are less than 6

Recipient exclusion criteria:
1. More than 2 previous failed oocyte donation cycles
2. Severe male factor infertility in partner

Study & Design

• Study Type: Interventional
• Study Design: Not specified