Embryo transfer with intrauterine application of human chorionic gonadotropin (hCG) to improve implantation- and pregnancy rates - a randomized controlled study

Not Applicable

• Conditions: N46; N97; Male infertility; Female infertility

• Registration Number: DRKS00026832
• Lead Sponsor: IVF-Zentren Prof. Zech, Pilsen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-12-19
• Study Start: 2021-10-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 1252

Inclusion Criteria

Included were all fresh blastocyst transfers on day 5 after ovum pick up

Exclusion Criteria

Female age =44 years (no age limit for male partner)
Known chromosomal aberration either by female or by male partner
IVF-cycles with preimplantation genetic analysis
IVF-cycles with use of donor oocytes
Patients with recurrent implantation failure (=3 negative IVF-cycles)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Implantation rate (number implanted embryos/ number transfered embryos; pregnancy rate: number positive pregnancy tests (beta-hCG) / number embryo transfers, clinical pregnancy rate: number of verified pregnancy tests by fetal heart beat / number embryo transfers; miscarriage rates: miscarriages/ number of embryo transfers; Live birth rates: number of deliveries / embryo transfers <br>

Secondary Outcome Measures

Name	Time	Method
Miscarriage rate after foetal heartbeat (miscarriages /verfied ckinical pregnancies)<br>Live birth rate (Live birth / embryos transferred)