In vitro human preimplantation embryo development in an adapted culture system based on human uterine fluid composition and uterine pH.

• Conditions: subfertiliteit; infertility; subfertility

• Registration Number: NL-OMON49697
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 700

Inclusion Criteria

Vital thawed human left-over preimplantation embryos, consisting of a minimum
of 5 blastomeres that comprise *50% of the whole embryo, that were donated for
research.

Exclusion Criteria

Of all human left-over day 3 or 4 embryos that were donated for research:
embryos that did not survive the freeze-thawing procedure or embryos that
consist of less than 5 blastomeres and/or are less than 50% vital.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the blastocyst formation rate. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes are embryo quality based on morphological assessment and<br /><br>cell count, embryo metabolism, embryo gene expression, and embryo methylation<br /><br>pattern.</p><br>