To compare the effectiveness of dexmedetomidine versus combination of lignocaine and dexamethasone on postoperative sore throat in patients undergoing elective laparoscopic surgery in Trendelenburg position

This is a prospective , double blind, single centric, three arm, randomized controlled trial comparing two groups of anaesthetic drugs with eachother and with placebo for prevention of post operative sore throat in 135 adult patients of either sex undergoing elective laparoscopic surgery in Trendelenburg position. The patients shall be randomly allocated to either of the three groups D (1microgram/kg dexmedetomedine),group LS(ligocaine 1.5mg/kg+8mg dexamethasone),group N(normal saline). These drugs are expected to reduce the incidence and severity of post operative sore throat both at rest and during swallowing. The primary outcome measure is postoperative sore throat at 15mins, 1h, 6h,12h and 24h postoperatively. The secondary outcome measures are postoperative sore throat on swallowing at 15min, 1h, 6h, 12h and 24 h post operatively, total morphine consumption measured at 24h postoperatively, percentage of glottic opening score measured at 2sec before intubation and blood staining of  the endotracheal tube noted 30sec post extubation.