A retrospective study on the effects of gene polymorphisms on postoperative pain management in patients undergoing major abdominal surgery

Not Applicable

Recruiting

• Conditions: Pain

• Registration Number: JPRN-UMIN000000924
• Lead Sponsor: Tokyo Metropolitan Institute of Medical Science

Brief Summary

American Society of Human Genetics (ASHG) 57th Annual Meeting Japanese Society of Clinical Neuropsychopharmacology (JSCNP) 19th Annual Meeting / Japanese Society of Neuropsychopharmacology (JSNP) 39th Annual Meeting American Society of Human Genetics (ASHG) 60th Annual Meeting Japanese Society of Clinical Neuropsychopharmacology (JSCNP) 20th Annual Meeting / Japanese Society of Neuropsychopharmacology (JSNP) 40th Annual Meeting Japanese Society of Clinical Neuropsychopharmacology (JSCNP) 22th Annual Meeting / Japanese Society of Neuropsychopharmacology (JSNP) 42th Annual Meeting European Human Genetics Conference 2013 XXIst World Congress of Psychiatric Genetics Method of evaluating drug-sensitivity by analyzing the mu-opioid receptor gene Method of evaluating drug-sensitivity by analyzing the GIRK channel genes Hayashida M, Nagashima M, Satoh Y, Katoh R, Tagami M, Ide S, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Komatsu H, Sora I, Fukuda K, Koga H, Hanaoka K, Ikeda K. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype. Pharmacogenomics. 2008 Nov;9(11):1605-16. Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K. Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery. PLoS One. 2009 Sep 16;4(9):e7060. Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry. 2014 Jan;19(1):55-62. doi: 10.1038/mp.2012.164. Epub 2012 Nov 27.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-12-03
• Study Completion: 2015-01-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

Patients less than 20 years and more than 75 years or those with severe complications

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Associations between gene polymorphisms and postoperative opioid requirements or intensity of postoperative pain in patients who had undergone major abdominal surgery in the last several years