A prospective study on the effects of gene polymorphisms on postoperative pain management in patients undergoing orthognathic surgery

Not Applicable

Recruiting

• Conditions: Pain

• Registration Number: JPRN-UMIN000000925
• Lead Sponsor: Tokyo Metropolitan Institute of Medical Science

Brief Summary

American Society of Human Genetics (ASHG) 59th Annual Meeting 12th International Congress of Human Genetics (ICHG) / American Society of Human Genetics (ASHG) 61st Annual Meeting Japanese Society of Clinical Neuropsychopharmacology (JSCNP) 21th Annual Meeting / Japanese Society of Neuropsychopharmacology (JSNP) 41th Annual Meeting Japanese Society of Clinical Neuropsychopharmacology (JSCNP) 22th Annual Meeting / Japanese Society of Neuropsychopharmacology (JSNP) 42th Annual Meeting Purine 2012 European Human Genetics Conference 2013 XXIst World Congress of Psychiatric Genetics Method of evaluating drug-sensitivity by analyzing the voltage-dependent Ca2+ channel gene Method of evaluating drug-sensitivity by analyzing the adrenergic receptor genes Method of evaluating drug-sensitivity and vulnerability to diseases by analyzing the cyclic-AMP response element-binding protein gene Method of evaluating drug-sensitivity by analyzing several genes related to analgesia Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Nagashima M, Tagami M, Komatsu H, Sora I, Koga H, Kaneko Y, Ikeda K. Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009 Dec 15;147(1-3):194-201. doi: 10.1016/j.pain.2009.09.004. Epub 2009 Sep 26. Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry. 2014 Jan;19(1):55-62. doi: 10.1038/mp.2012.164. Epub 2012 Nov 27.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-12-03
• Study Completion: 2016-05-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Not provided

Exclusion Criteria

Patients less than 15 years and more than 60 years or those with severe complications

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Associations between gene polymorphisms and postoperative opioid requirements or intensity of postoperative pain during 24 hours after surgery