Use of Hyaluronic Acid Injection in Treatment of Idiopathic Carpal Tunnel Syndrome Versus Corticosteroid Injection Sonographically Guided
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- neuropathic pain VAS
研究概览
简要总结
carpal tunnel syndrome (CTS) is the most common compression syndrome in the upper extremities, CTS is characterized by typical anatomic changes, the most probable swelling of the median nerve in the proximal part of the CT.
Local infiltration of corticosteroids easily leads to atrophy of the median nerve, subcutaneous fat, and systematic complications, surgical treatment decision is always taken by the patient who sometimes wants to delay or avoid the surgery because of psychological or medical concerns, It would be interesting if low molecular weight sodium hyaluorinate injection is used as an alternative conservative treatment of CTS. This study aims to investigate if, and to what extent, hydro-dissection using 1% lidocain followed by injection of Sodium hyaluronate versus 1% lidocain followed by injection of 40 mg of triamcinolone acetonide, under ultrasound guidance.
详细描述
60 CT patients, blindly divided into two groups. Both will underwent median nerve hydro-dissection using 1% lidocain followed by group I injection of Sodium hyaluronate and group II injection of 40 mg of triamcinolone acetonide, under ultrasound guidance. Baseline VAS pain and nerve conduction study, patient satisfaction, and therapeutic duration, will be determined in 2nd week, 3rd and 6th month after the procedure. US measurements of the median nerve cross-sectional area (CSA) in the CT inlet will be compared pre and post procedure in 6th month and use NCS results as the gold standard diagnostic test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with mild or moderate carpal tunnel diagnosed by nerve conduction study
排除标准
- •secondary carpal tunnel to any other disease and peripheral neuropathy patients
研究组 & 干预措施
corticosteroid with ultrasound guided
median nerve hydro-dissection using 1% lidocain followed by injection of corticosteroid Ultrasonographically guided
干预措施: ultrasound (Device)
sodium hyaluorinate ultrasound guided
median nerve hydro-dissection using 1% lidocain followed by low molecular weight sodium hyaluronate (Hyalgan) injection ultrasonographically guided
干预措施: Sodium Hyaluronate (Drug)
sodium hyaluorinate ultrasound guided
median nerve hydro-dissection using 1% lidocain followed by low molecular weight sodium hyaluronate (Hyalgan) injection ultrasonographically guided
干预措施: ultrasound (Device)
sodium hyaluorinate ultrasound guided
median nerve hydro-dissection using 1% lidocain followed by low molecular weight sodium hyaluronate (Hyalgan) injection ultrasonographically guided
干预措施: Sodium Hyaluronate and 1% lidocain (Drug)
corticosteroid with ultrasound guided
median nerve hydro-dissection using 1% lidocain followed by injection of corticosteroid Ultrasonographically guided
干预措施: Sodium Hyaluronate and 1% lidocain (Drug)
corticosteroid with ultrasound guided
median nerve hydro-dissection using 1% lidocain followed by injection of corticosteroid Ultrasonographically guided
干预措施: Corticosteroid and 1%lidocain (Drug)
结局指标
主要结局
neuropathic pain VAS
时间窗: 2 weeks
0-10 VAS scale in the 2nd week after injection
次要结局
- nerve conduction study(1 month)
研究者
Manal Hassanien
Principal Investigator
Assiut University
