T Regulatory Cells in Lupus Nephritis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 65
- 主要终点
- Association of FoxP3 and activity index
研究概览
简要总结
- To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs .
- To compare the functional capacity of T regs in LN and in normal individuals.
详细描述
Lupus Nephritis (LN) encompasses a group of glomerulonephrites, that occur in association with systemic lupus erythematosus (SLE). The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells. The regulatory T cells (T regs ) are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases. The main marker of Tregs is FoxP3 (forkhead box protein 3) positivity. Moreover, It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases. Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adults both genders clinical diagnosis of lupus nephritis
排除标准
- •patients diagnosed with other renal pathologies, e.g. diabetic kidney disease
结局指标
主要结局
Association of FoxP3 and activity index
时间窗: baseline
correlation between level of FoxP3 and activity index in the group with active LN.
Tregs in normal and lupus participants
时间窗: baseline
mean difference of suppression capacity of Tregs between normal participants and patients with active LN.
FoxP3 between groups
时间窗: baseline
mean difference of FoxP3 between groups.
次要结局
未报告次要终点
研究者
Mohamed AbdEllah Ahmed Hussein
Principal Investigator
Assiut University