Comparison of The Effect of A-PRF and L-PRF Application to The Palatal Region on Quality of Life and Wound Healing After Free Gingival Graft Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Epithelialization
研究概览
简要总结
Different approaches are used to reduce post-operative complications associated with the palatal wound site after free gingival graft (FGG) harvesting. The aim of this study was to compare the effects of L-PRF and A-PRF on palatal wound healing after free gingival graft harvesting and patients' quality of life.
详细描述
Thirty-six patients between the ages of 18 and 60 years (11 males and 25 females) who had completed Phase 1 periodontal treatments and for whom FGG surgery was indicated for isolated gingival recession defects limited to one or two teeth with shallow vestibule and insufficient keratinized or attached gingival width were included in the present study.
Three different treatments were performed on palatal wound areas: L-PRF (L-PRF group, n = 12), A-PRF (A-PRF group, n = 12) and palatal stent (control group, n = 12) OHIP-14 scores, VAS scores (for pain), analgesic tablet intake, and epithelialization condition were recorded for different time points.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients ≥18 years requiring FGG surgery because of shallow vestibule and insufficient keratinized/attached gingival width
排除标准
- •no smoking /no alcohol use,
- •not suffering from any systemic disease that could impair the healing of wounds,
- •pregnancy or lactation,
- •Previous graft harvesting from the same site.
结局指标
主要结局
Epithelialization
时间窗: 1 month
Hydrogen peroxide (H2O2) test was used to evaluate the integrity of epithelialization
次要结局
- Pain at Palatal wound area(First 7 days)
- Oral health-related quality of life (OHRQoL)(7 and 14 days after free gingival graft surgery)
研究者
Prof.Dr. Mehmet Sağlam
Principle Investigator
Izmir Katip Celebi University