Comparison Of Intravenous Infusion of Dexmedetomidine Versus Labetalol for Attenuation of Hemodynamic Stress Response During Laryngoscopy and Intubation
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Dexmeditomidine 1µ/Kg given slowly over 10 minutes intravenously 5 minutes prior to induction, attenuates the cardiovascular responses to laryngoscopy and intubation in a better manner than Labetalol 0.25mg/Kg.
研究概览
简要总结
Tachycardia hypertension and dysrhythmias all occur during Laryngoscopy and intubations. The consequent rise in rate or pressure may result in myocardial oxygen demand which exceeds the oxygen supply resulting in myocardial ischemia. This response is sympathetically mediated and can be attenuated by various drugs that block sympathetic activity and other drugs like calcium channel blocking drugs Lignocaine and magnesium sulphate.
This study aims at comparing efficacy of dexmedetomidine versus Labetalol in attenuating hemodynamic stress response during laryngoscopy and intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Patients of ASA grade 1 and 2 who are undergoing elective surgery under general anesthesia 2 Patients who consent to participate in the study 3 Patients having informant available.
排除标准
- •1 Difficult airway 2 Hypertension 3 Diabetes mellitus 4 ischemic heart disease 5 renal diseases 6 Cerebrovascular Disease • Patients on beta blockers alpha blockers • Bronchial asthma • Allergy to study drug.
结局指标
主要结局
Dexmeditomidine 1µ/Kg given slowly over 10 minutes intravenously 5 minutes prior to induction, attenuates the cardiovascular responses to laryngoscopy and intubation in a better manner than Labetalol 0.25mg/Kg.
时间窗: post intubation vitals are measured every 3minutes for first 15minutes
次要结局
- To observe the effect of Dexmedetomidine in attenuating the hemodynamic stress response during Laryngoscopy and intubation(2)To observe the effect of labetalol in attenuating hemodynamic stress response during Laryngoscopy and Intubation)
研究者
Dr Ambati Mounika
Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation