Effect of Intradialytic Resistance Training on Circulatory miRNA Profile and Muscle Strength in Haemodialysis Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 90
- Locations
- 2
- Primary Endpoint
- Change in lower extremity muscle strength
Study Overview
Brief Summary
The study will investigate the effects of an intradialytic resistance training on miRNA´s expression and muscle strength in haemodialysis patients.
Detailed Description
Chronic kidney disease (CKD) is accompanied by distortions of immune functions and acceleration of inflammation processes. Regular exercise has shown great potential for improving the health-related parameters of CKD patients. Moreover, muscle strength is considered to be an important predictor of protein- and energy- wasting, inflammation, quality of life and mortality in CKD patients. The behaviour and individual variability of adaptation to regular, controlled, supervised physical activities in CKD patients are not well defined and understood. The understanding of molecular adaptation mechanisms, represented by the epigenetic impact of exercise on renal specific miRNA´s expression, is necessary for future improvements in clinical practice. Monitoring pro- and anti-inflammation genes activity, their transcription factors and expression of miRNA molecules (influencing the signalling pathways of specific genes) will enable us to draft a new transcription and translation model for exercise-induced adaptation in CKD patients. Additionally, our results will indicate the clinical value of selected markers for the diagnostics and prognostics of disease.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 30 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All patients over 30 years of age, diagnosed with chronic kidney disease, treated with haemodialysis are eligible for our study.
Exclusion Criteria
- •Lower extremity amputation, severe dementia or retardation, acute intercurrent disease and probability of one year mortality higher than 25 % according to Charlson Comorbidity Index (CCI) are the exclusion criteria for participation in the study.
Outcomes
Primary Outcomes
Change in lower extremity muscle strength
Time Frame: Before the intervention, 1-5 days after the completion of the 12-week intervention and after 3 months follow up
Change in maximal voluntary force produced during knee extension, leg flexion, extension and hip abduction, adduction will be assessed by dynamometer
Secondary Outcomes
- Change in activity of circulatory miRNA molecules involved in TRIM63 and IGF-1 signalling pathways(Before the intervention and 1-5 days after the completion of 12-week intervention)
- Change in renal specific clinical data(Before the intervention, 1-5 days after the completion of the 12-week intervention and after 3 months follow up)
- Change in score on the Hospital Anxiety and Depression Scale(Before the intervention and 1-5 days after the completion of 12-week intervention)
- Change in score on the Kidney Disease Quality of Life(Before the intervention and 1-5 days after the completion of 12-week intervention)
Investigators
Jaroslav Rosenberger
Jaroslav Resenberger, MD, PhD.
Pavol Jozef Safarik University