Fluid bolus therapy in children with septic shock
Not Applicable
- Conditions
- Health Condition 1: I958- Other hypotension
- Registration Number
- CTRI/2021/01/030320
- Lead Sponsor
- All India Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Children 2 month to 17 years of age with features of septic shock ââ?¬â?? defined as children who have a suspected infection manifested by hypothermia or hyperthermia and have at least two clinical signs of decreased perfusion with or without hypotension
Exclusion Criteria
Children receiving boluses before enrolment
Children with chronic kidney disease.
Children with fulminant myocarditis
Children with dengue shock syndrome
Children with malaria
Children with severe anemia (Hb <5 gm/dl) and
�Severe acute malnutrition (wt/ht <-3 SD)
�Post-arrest shock and cardiac dysfunction
�Moribund patients in who anticipated survival is < 24 hrs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MortalityTimepoint: Death or discharge from the PIC
- Secondary Outcome Measures
Name Time Method ICU free daysTimepoint: Measured at day 28 of enrollment;Organ dysfunction using pediatric Sequential Organ Failure Assessment(pSOFA)scoreTimepoint: Measured at 24, 48 and 72 hours;Proportion having fluid overload in first 24 hours , 48 hours and 72 hoursTimepoint: Measured at 24 hours, 48 hours and 72 hours of resuscitation;Vasoactive inotrope scoreTimepoint: Measured at 24 48 and 72 hours;Ventilator free daysTimepoint: Measured at day 28 since enrollment