Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 主要终点
- Amniotic membrane retention
研究概览
简要总结
A retrospective study including 22 patients who have undergone amniotic membrane transplant in our unit up till 2016. Confocal microscopy and anterior segment optical coherence tomography (ASOCT) were performed to assess the retention of amniotic membrane and to detect any corneal structural changes. Comparison was made with 5 controls who had bullous keratopathy awaiting endothelial keratoplasty.
详细描述
This retrospective cohort study (CREC Ref No.: CRE-2013.687) was approved by the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee. All patients who had AMT done due to symptomatic bullous keratopathy at the Prince of Wales Hospital and Alice Ho Miu Ling Nethersole Hospital (from 1998 onwards till June 2016) were invited back for confocal microscopy and anterior segment optical coherence tomography (ASOCT) at the clinic by the principal investigator (GS) from October to November 2016.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients who have undergone amniotic membrane transplant in our cluster up till
- •Patients who have bullous keratopathy on conservative treatment such as lubricants, bandage contact lens
排除标准
- •patients who refuse to participate in the study, have passed away or cannot return for the clinical assessment will be excluded.
结局指标
主要结局
Amniotic membrane retention
时间窗: from date of operation till 2016
Amniotic membrane retention in the cornea was assessed with confocal microscopy
次要结局
- Pain(from date of operation till 2016)
研究者
Gillian Siu
Resident Specialist
Prince of Wales Hospital, Shatin, Hong Kong