Optimisation of the peri-operative mechanical ventilation in normal-weight and morbid obese patients by PEEP-Titration using electric impedance tomography – a randomised controlled clinical trial

Not Applicable

• Conditions: E66.9; Obesity, unspecified

• Registration Number: DRKS00004199
• Lead Sponsor: Klinik und Poliklinik für Anästhesiologie und IntensivtherapieUniversitätsklinikum Leipzig

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07-27
• Study Completion: 2017-12-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Age >= 18 years
- obesity grpup: BMI = 35 kg/m²
- group with normal weight: BMI = 18,5 to 25 kg/m²
- need for surgery with intermediate or high risk for post–operative pulmonary
complications (ARISCAT score higher than or equal to 26)
- informed consent

Exclusion Criteria

- Need for neurosurgery, cardiothoracic, head, neck and liver surgery
- Persistent hemodynamic instability
- History of previous severe chronic obstructive pulmonary disease (COPD) or acute lung injury
- Pregnancy (excluded by laboratory analysis)
- severe cardiac disease (NYHA III or IV, or acute coronary syndrome, or persistent ventricular tachyarrhythmias)
- Neuromuscular disease of all types
- Surgery longer than 30 minutes within last 30 days of all types
- cardiac peacemaker or other implanted stimulation devices

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
postoperative oxygenation, measured by ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) directly before extubation

Secondary Outcome Measures

Name	Time	Method
- oxygenation at different times<br>- End-expiratory lung volume (EELV)<br>- post–operative pulmonary and extra–pulmonary organ failure (SOFA)<br>- days in intensive care unit and hospital