To compare the effect of drug Dexmedetomidine with a placebo on the blood pressure and heart rate in patients undergoing Laparoscopic gall bladder removal surgery
Phase 4
- Conditions
- Health Condition 1: R098- Other specified symptoms and signsinvolving the circulatory and respiratory systems
- Registration Number
- CTRI/2020/06/026037
- Lead Sponsor
- Dr Dikshita Goswami
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Patients with valid consent
2) American Society of Anaesthesiologists Physical Status 1 or 2
3) Undergoing elective laparoscopic cholecystectomy requiring endotracheal intubation
Exclusion Criteria
1) Patient refusal
2) Patients having known allergy either to Dexmedetomidine or any of the drugs to be administered
3) Patients with airway problems (anticipated/ unanticipated difficult airway)
4) Pregnant or lactating females
5) Patients with known history of substance abuse
6) Patients with hypotension, bradycardia or pre existing heart block
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the effect of Dexmedetomidine infusion on haemodynamic stability (Systolic and Diastolic Blood Pressure, Mean Arterial Pressure and Heart Rate) in response to the following events in patients undergoing laparoscopic cholecystectomy: laryngoscopy and endotracheal intubation, creation of pneumoperitoneum and extubation.Timepoint: Before starting infusion, 10 minutes after starting infusion, 1 minute after laryngoscopy and intubation, after pneumoperitoneum at- 1 minute, 15 minutes, 30 minutes, 45 minutes, 60 minutes and 1 minute after extubation
- Secondary Outcome Measures
Name Time Method To oberve the effects on analgesia in immediate post operative periodTimepoint: post operatively at 1 minute, 15 minutes, 30 minutes and 60 minutes after extubation;To observe the effects on level of sedation at the end of surgeryTimepoint: post operatively at 1 minute, 15 minutes, 30 minutes and 60 minutes after extubation;To record other relevant observations, if anyTimepoint: From the start of infusion at 10 minutes prior to induction of anaesthesia till 60 minutes after extubation