Neuroimaging of Pavlovian Fear Conditioning Processes in Patients With Pathological Anxiety

Not Applicable

• Conditions: Panic Disorder; Social Phobia; Anxiety Disorders; Phobia; Post Traumatic Stress Disorder
• Interventions: Behavioral: Novelty facilitated extinction; Behavioral: Standard Extinction

• Registration Number: NCT03498599
• Lead Sponsor: University of Texas at Austin

Brief Summary

The purpose of this study is to use functional magnetic resonance imaging to investigate how the human brain learns to form associations between neutral and emotional stimuli. The study is based on the basic principles of Pavlovian conditioning.

When someone learns that a neutral stimulus (such as the sound of a bell) predicts an unpleasant stimulus (such as a mild electrical shock), the neutral stimulus takes on the properties of an emotional stimulus.

The investigators are interested in the neural processes involved in this learning in people with a clinical anxiety disorder and posttraumatic stress disorder (PTSD).

Detailed Description

This study uses functional MRI in people with anxiety and stress-related disorders to evaluate the neural correlates of fear conditioning and extinction. During fear conditioning participants see a picture of a face that predicts a mild electrical shock to the wrist. Participants then return the next day to the scanner for a test of fear expression 24-hours after fear conditioning. The investigators are simultaneously measuring autonomic arousal in the scanner using measures of skin conductance responses (i.e., sweating).

The primary objective of this study is to evaluate different forms of Pavlovian fear extinction in patients who suffer from pathological anxiety. The investigators are interested in the effects of extinction and extinction retention over a delay in regions that are known to show abnormalities in anxiety populations. This includes the amygdala, ventromedial prefrontal cortex, and the hippocampus.

The study is testing behavioral strategies and does not include any pharmacological manipulations.

Study Timeline

• Study Start: 2017-08-01
• Study First Submitted: 2018-02-15
• Status Verified: 2018-04
• Study First Submitted QC: 2018-04-12
• Last Update Submitted: 2018-04-12
• Study First Posted: 2018-04-13
• Last Update Posted: 2018-04-13
• Primary Completion: 2020-06
• Study Completion: 2020-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Male or female volunteer aged 18-50 years old
2. Able to understand procedures and agree to participate in the study by giving written informed consent.
3. Speaks fluent English.
4. Not taking illicit drugs.
5. No history of neurological problems.
6. Eligible for MRI, including no metal in the body or body piercings that cannot be removed.

Exclusion Criteria

1. Current comorbid Axis 1 psychiatric disorder
2. Women who are current pregnant or breastfeeding
3. Lifetime diagnosis of any psychotic disorder, cognitive suicidal ideation, substance abuse or alcohol dependence, hoarding.
4. Medications that act on the central nervous system that interfere with interpretation of the findings (e.g., painkillers, Adderall)
5. Claustrophobia
6. Patients who are unable to comply with procedures or assessments.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Novelty facilitated extinction	Novelty facilitated extinction	Behavioral intervention. After Pavlovian fear conditioning, the shock is omitted and replaced by a novel, surprising, and neutral auditory tone.
Standard extinction	Standard Extinction	The shock is omitted during standard extinction

Primary Outcome Measures

Name	Time	Method
Changes in functional magnetic resonance imaging (fMRI)-BOLD (blood-oxygen-level dependent) signal in sensory, prefrontal, and limbic regions during a study on the neurobiology of Pavlovian fear conditioning in humans	Only on the day of the experiment	We are measuring increases in the BOLD signal in response to visual stimuli during a Pavlovian conditioning task in humans.

Secondary Outcome Measures

Name	Time	Method
Skin conductance responses evoked during a Pavlovian fear conditioning task in humans as an index of physiological arousal.	Only on the day of the experiment	Electrodermal activity collected from the hand that measures increases in sweating, taken as an indicator of Pavlovian fear conditioning

Trial Locations

Locations (1)

The University of Texas at Austin; 🇺🇸 Austin, Texas, United States