Pathophysiological mechanisms of impaired urinary concentrating ability in hypothyroidism.

Completed

• Conditions: hypothyroidism; urinary concentrating ability; 10043739; 10038430

• Registration Number: NL-OMON40625
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

patient with differentiated thyroid carcinoma
Have the capacity to understand and willingness to sign an informed consent form.
Aged 18-65 years
Estimated kidney function, eGFR >60 mL/min per 1.73 m2

Exclusion Criteria

Alcohol abuse
Other malignancy
Clinically relevant active systemic disease (such as autoimmune or infectious diseases)
Pregnancy
Use of drugs interfering with thyroid hormone metabolism (e.g. antiepileptic drugs, amiodarone, and lithium) or influencing renal concentration capacity (i.e. diuretics)
Other primary thyroid disease
History of diabetes insipidus, diabetes mellitus, adrenal deficiency, chronic kidney disease
Urinary tract infection or menstruation at the time of inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome will be a significant difference in maximal urine<br /><br>osmolality after water deprivation in euthyroid and hypothyroid state.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome is a difference in heart rate, urinary water and salt<br /><br>transporter excretion in urinary microvesicles (both protein and RNA abundance)<br /><br>and vasopressin/ copeptin levels after water deprivation.</p><br>