Comparison of Quadratus Lumborum Block and Erector Spina Plane Block in Nephrectomy

Not Applicable

Completed

• Conditions: Pain, Postoperative; Postoperative Complications
• Interventions: Procedure: Erector Spina Plane Block; Procedure: Quadratus Lumborum Block 2

• Registration Number: NCT04459624
• Lead Sponsor: Eskisehir Osmangazi University

Brief Summary

Postoperative pain is important due to the limitation of physical functions, delay in recovery of quality of life, long-term opiate use, length of hospital stay, increased care costs and early postoperative pain trigger chronic pain. It is associated with postoperative morbidity. Multimodal analgesia techniques with fascial plan blocks are frequently used.The investigators aimed to evaluate the effect of QLB2 and ESP on postoperative pain scores in nephrectomy surgery, total opiate consumption, initial analgesia requirement, additional analgesia consumption, patient and surgeon satisfaction.

Detailed Description

At the end of the operation, patients will be randomly divided into 2 groups as Group E (ESP block) and Group Q (QLB). The blocks will be administered under general anesthesia in lateral position by same anesthesiologist. Group E (ESP block) will be applied 20 ml of %0.25 bupivacaine between the erector spina muscle and transverse process at the 8th thoracic level. Group Q (QLB2 block) will be applied 20 ml of %0.25 bupivacaine at lumbar interfacial triangle (LIFT). At the end of the operation, the patients with a Modified aldreate score ≥9 will be sent from the postoperative anesthesia unit. All patients will be equipped with an IV morphine patient-controlled analgesia (PCA) device. The solution will be prepared such that morphine is 0.5 mg / ml. PCA 1mg bolus dose will be delivered with 10 min lock-out time. In the postoperative period, the patient was evaluated by another researcher who blind to the groups at the 1st and 6th, 12th and 24th hours. Visual pain scores (VAS) in rest and movement, hemodynamic values, morphine consumption, initial analgesic requirement, nausea-vomiting score, ramsey sedation scale, length of hospital stay, patient and surgeon satisfaction, and postoperative complications will be recorded.

Study Timeline

• Study First Submitted: 2020-06-23
• Study First Submitted QC: 2020-07-06
• Study First Posted: 2020-07-07
• Study Start: 2020-07-20
• Primary Completion: 2021-07-20
• Study Completion: 2022-01-31
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-03
• Last Update Posted: 2022-02-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Partial or radical nephrectomy
• American Society of Anesthesiologist physical status I-III

Exclusion Criteria

• Infection in the incision area
• Coagulation disorder
• Known allergy history against to the study drugs
• Lack of adequate cognitive activity in the use of patient-controlled analgesia and VAS

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ESP block	Erector Spina Plane Block	Intervention: Erector Spina Plane Block will administer with 20 ml of % 0.25 bupivacaine
QLB 2 block	Quadratus Lumborum Block 2	Intervention: Quadratus Lumborum Block 2 will administer with 20 ml of % 0.25 bupivacaine

Primary Outcome Measures

Name	Time	Method
Effect of QLB2 and ESP on postoperative pain scores in nephrectomy surgery	24 hours	Visual analog scale at rest and movement (0 (no pain)-10 (unbearable pain))

Secondary Outcome Measures

Name	Time	Method
Total opiate consumption	24 hours	Total morphine patient control analgesia prepared 0.5 mg / ml. PCA 1mg bolus dose will be delivered with 10 min lock-out time. Follow up morphine consumption at postoperative 24 hours

Trial Locations

Locations (1)

Eskisehir Osmangazi Univercıty; 🇹🇷 Odunpazarı, Eskisehir, Turkey